Chloe, a diamond-clad ultra-pampered Beverly hill Chihuahua find herself be “puppy-sit” by the niece, Rachel, of her proprietor when she leave for Europe for one of her manner show. Rachel is enjoy her auntie’s affluent place but can’ t resist a weekend trip to United Mexican States with her friend. With Chloe in carryall, Rachel’s party rapidly disgust Chloe and she decide she will go place herself. Chloe rapidly get lose in United Mexican States and throw into a dog-fighting ring where she meet Delgado, an ex police force K9 who is at that place and find himself between his old enemy Diablo, the drug-lord’s dog who destroy his calling, and Chloe. After salvage her and himself, Delgado agree to assist her get place and they get down their journeying across United Mexican States for Beverly hill. Meanwhile, Rachel has enlist the aid of her auntie’s nurseryman and Papi, the nurseryman’s Chihuahua who’s loony about Chloe, to assist happen and salvage her.