While in chase of cop Johnathan sculpt, his diabolic nemesis, Faustus, send his disciple Alexandria to run down the talisman that will set him free. Meanwhile, the Ghoulies happen their way through an unfastened porthole and onto the street of L.A., make lunacy and mayhem as they seek for a way to get back place. As the organic structure count rise, it become an ultimate conflict between a diabolic slayer, a rule-breaking cop, and our favourite animal from the Hell!